Dupixent (dupilumab)

Product Name:

Dupixent (dupilumab)

Categories: Allergy, Dermatology, Immunology, Pulmonology, Rheumatology

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Table of Contents

Dupixent (dupilumab)

Product Category

Immunology / Dermatology / Respiratory Therapy

Brand Name

Dupixent

Generic Name or Biosimilar

No generic or biosimilar available

Active Ingredient

Dupilumab

Prescription Status

Prescription-only

Targeted Conditions

  • Moderate-to-severe atopic dermatitis (eczema) in adults and children ≥6 months
  • Moderate-to-severe asthma in patients ≥6 years not controlled with inhaled corticosteroids
  • Chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults
  • Eosinophilic esophagitis (EoE) in patients ≥1 year
  • Prurigo nodularis in adults

Off-Label Usage

  • Chronic spontaneous urticaria (under investigation)
  • Other eosinophilic disorders (limited evidence)

(Off-label usage should be guided by an immunologist or dermatologist and is not formally approved by FDA, Health Canada, or COFEPRIS.)

Drug Classification Overview

Dupixent is a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling.
By blocking these cytokines, it reduces type 2 inflammation, which plays a key role in atopic dermatitis, asthma, CRSwNP, and other allergic or eosinophilic conditions.

Manufacturer in the USA, Mexico, and Canada

USA: Regeneron Pharmaceuticals, Inc. / Sanofi US
Mexico: Sanofi-Aventis de México, S.A. de C.V.
Canada: Sanofi Canada

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Equivalent formulation and dosing across all three countries
  • Differences may include injector type (prefilled pen vs syringe)
  • Cold chain shipping required

Average Retail Price (Monthly Treatment)

Canada: Approximate savings of 40–60% vs U.S. retail
Mexico: Approximate savings of 35–55% vs U.S. retail

Savings vary depending on local regulations, pharmacy access, and cold chain logistics.

Where to Buy USA

  • CVS, Walgreens, Rite Aid, Walmart, Costco, Kroger, Albertsons, Sam’s Club, Publix, Target (via CVS Pharmacy), and specialty mail-order pharmacies

Availability may require prior authorization and insurance approval through specialty pharmacies.

Storage Requirements

  • Store refrigerated at 2°C to 8°C (36°F to 46°F)
  • Do not freeze. Protect from light.
  • May be kept at room temperature for up to 14 days if needed

Key Benefits

  • Reduces symptoms of eczema, asthma, CRSwNP, EoE, and prurigo nodularis
  • Improves quality of life and reduces flares
  • Steroid-sparing therapy option
  • Subcutaneous self-administration
  • Well-tolerated with favorable safety profile

Shipping from Canada

Dupixent is accessed through licensed Canadian pharmacies regulated by Health Canada. MedicalMex coordinates access through certified specialty pharmacies and treatment centers.

MedicalMex facilitates:

  • Prescription verification and coordination
  • Cold chain–compliant shipping
  • Telehealth consultations with licensed specialists if needed
  • Insurance and payment support
  • Case management and patient concierge support

Buying from Mexico

Dupixent is available through certified pharmacies in Mexico regulated by COFEPRIS. MedicalMex facilitates patient access through licensed treatment centers.

MedicalMex facilitates:

  • Prescription handling with licensed physicians
  • Telehealth consultations if required
  • Travel coordination if in-person access is needed
  • Cold chain–compliant logistics
  • Concierge bilingual support

Side Effects

  • Common: Injection site reactions (redness, swelling, pain); Conjunctivitis; Headache
  • Moderate: Keratitis; Eye pruritus; Eosinophilia
  • Serious: Hypersensitivity reactions; Anaphylaxis (rare)

Patients should report persistent eye symptoms, severe allergic reactions, or unexpected side effects immediately.

Warnings and Precautions

  • Not for use in acute asthma attacks
  • Monitor for eye-related adverse events
  • Avoid live vaccines while on treatment
  • Safety in pregnancy and breastfeeding not fully established

Alternative Medications (by Indication)

Atopic dermatitis: Topical steroids, calcineurin inhibitors, JAK inhibitors (e.g., upadacitinib)
Asthma: Inhaled corticosteroids, biologics (omalizumab, mepolizumab)
CRSwNP: Surgery, corticosteroids, omalizumab
EoE: Swallowed topical corticosteroids, diet modification
Prurigo nodularis: Other biologics in clinical trials

Medication FAQs

Dupixent treats atopic dermatitis, asthma, CRSwNP, eosinophilic esophagitis, and prurigo nodularis by targeting type 2 inflammation pathways.

It is given by subcutaneous injection every 2–4 weeks, depending on indication and patient age.

No routine labs are required, but patients should be monitored for side effects and overall response.

No. It is a biologic therapy that targets IL-4 and IL-13 signaling.

Some patients experience improvement in 2–4 weeks, with continued benefit over months.

Yes. Dupixent is a prescription-only medication and must be prescribed by a licensed healthcare provider.

It may be combined with topical or systemic therapies, but always under physician supervision.

Yes. MedicalMex facilitates access through licensed pharmacies and treatment centers in both countries.

Yes. It must be stored properly in a cooler with temperature control if travel is required.

Concierge services including prescription validation, Telehealth consultations, logistics, cold chain shipping, and bilingual patient support.