Product Name:

Mavyret (glecaprevir / pibrentasvir)

Categories: Hepatology, Infectious Diseases

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Table of Contents

Mavyret (Glecaprevir/Pibrentasvir)

Product Category

Hepatitis C Antiviral Therapy – Direct-Acting Antiviral (DAA)

Brand Name

Mavyret

Generic Name or Biosimilar

No

Active Ingredient

Glecaprevir and Pibrentasvir

Prescription Status

Prescription-only

Targeted Conditions

Mavyret is FDA-approved for the treatment of:

  • Chronic hepatitis C virus (HCV) infection in adults and children 3 years and older
  • HCV genotypes 1 through 6, including those with or without compensated cirrhosis
  • Patients with or without prior treatment experience

Off-Label Usage

While Mavyret is primarily used for HCV, off-label exploration includes:

  • Shortened treatment durations in specific patient populations
  • Retreatment of certain DAA-experienced HCV cases (under physician supervision)
  • Post-liver transplant HCV recurrence (in select cases)

All off-label use must be under expert hepatology or infectious disease care.

Drug Classification Overview

Mavyret is a fixed-dose combination direct-acting antiviral (DAA) medication. Glecaprevir inhibits HCV NS3/4A protease, and pibrentasvir inhibits HCV NS5A protein — two essential viral replication components. This dual mechanism makes Mavyret effective across all major HCV genotypes.

Manufacturer in the USA, Mexico, and Canada

  • USA: AbbVie Inc.
  • Canada: AbbVie Corporation
  • Mexico: AbbVie México S.A. de C.V.

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Available as oral tablets in all three countries
  • Same dual-acting formulation, though tablet size, blister packaging, or labeling may differ
  • All formulations are verified and regulated by national health authorities (FDA, COFEPRIS, Health Canada)

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

  • Canada: ~55–65% savings vs U.S. retail
  • Mexico: ~40–50% savings vs U.S. retail

Savings vary based on availability, prescription requirements, controlled handling protocols, and cold chain needs if applicable.

Where to Buy USA

Mavyret is available at:

  • CVS
  • Walgreens
  • Rite Aid
  • Walmart
  • Costco
  • Kroger
  • Albertsons
  • Sam’s Club
  • Publix
  • Target (via CVS Pharmacy)
  • Online mail-order specialty care pharmacies

Availability depends on insurance coverage, specialty pharmacy access, and medical criteria for HCV treatment.

Storage Requirements

Store at room temperature (68°F–77°F / 20°C–25°C). Protect from moisture. Keep in original packaging until use. Avoid exposure to excessive heat.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • Approved for treatment of all six major HCV genotypes
  • Shortened treatment duration — as little as 8 weeks in many cases
  • Highly effective, with cure rates over 95%
  • Well tolerated in most patients
  • No ribavirin required
  • Option for pediatric patients (age 3+) and post-transplant individuals

Side Effects

Common side effects:

  • Headache
  • Fatigue
  • Nausea
  • Diarrhea

Less common but serious effects:

  • Elevation of liver enzymes in patients with advanced liver disease
  • Drug-drug interactions with statins, certain anticonvulsants, HIV medications
  • Hepatitis B reactivation in co-infected individuals

Warnings and Precautions

  • Contraindicated in patients with severe liver impairment (Child-Pugh C)
  • Do not use with strong P-gp or CYP3A inducers (e.g., rifampin, carbamazepine)
  • Reactivation of hepatitis B may occur — screen for HBV before starting treatment
  • Close monitoring in transplant recipients or patients with complex medication regimens
  • Must be taken with food to ensure absorption

Alternative Medications (by Indication)

  • Epclusa (sofosbuvir/velpatasvir)
  • Harvoni (sofosbuvir/ledipasvir)
  • Zepatier (elbasvir/grazoprevir)
  • Vosevi (sofosbuvir/velpatasvir/voxilaprevir) – used for treatment-experienced patients
  • Ribavirin (used adjunctively in some resistant cases)

Medication FAQs (Patient-Oriented Answers)

Mavyret treats chronic hepatitis C infection in both adults and children over 3 years of age. It works for all six genotypes of HCV.

Most patients take Mavyret for 8 weeks. Some may require 12 or 16 weeks depending on their treatment history and liver condition.

Yes, in most cases. Mavyret has a cure rate of over 95% when taken as prescribed.

Yes, Mavyret should be taken with food to help the body absorb the medication effectively.

Yes, it is approved for pediatric use in children aged 3 years and older.

Common side effects include headache, tiredness, and nausea. Serious side effects are rare but may include liver enzyme changes or drug interactions.

No, it is stored at room temperature, but should be kept in the original blister pack and away from excess moisture.

Yes, but you must inform your doctor. Drug interactions are possible, so careful monitoring is needed.

Yes. A valid prescription is required. We can coordinate this through your physician or assist through our certified medical network if needed.

We handle everything — from verifying your prescription and coordinating with licensed pharmacies in Canada or Mexico, to managing secure shipping and refill tracking — ensuring compliance, safety, and support.

No. As of now, there is no approved generic version of Mavyret in the United States, Canada, or Mexico.

Patients typically save between 55–65% from Canada and 40–50% from Mexico compared to U.S. retail prices.