Product Name:

Ocrevus (ocrelizumab)

Categories: Immunology, Neurology, Rheumatology

Discover Savings on Your Medication Access

Trusted concierge service, secure process, and real savings for patients in the U.S.

Table of Contents

Ocrevus (ocrelizumab)

Product Category

Neurology / Multiple Sclerosis

Brand Name

Ocrevus

Generic Name or Biosimilar

No

Active Ingredient

Ocrelizumab

Prescription Status

Prescription-only in the United States, Mexico, and Canada.

Targeted Conditions

  • Relapsing forms of multiple sclerosis (RMS), including relapsing-remitting disease.
  • Primary progressive multiple sclerosis (PPMS).

Off-Label Usage

  • Investigational in certain autoimmune conditions such as neuromyelitis optica spectrum disorder (NMOSD), though not approved.
  • Studied in some rare immune-mediated neurological disorders.

Drug Classification Overview

Ocrevus is a humanized monoclonal antibody that selectively targets CD20-positive B cells, which are believed to play a key role in abnormal immune responses that damage the myelin in multiple sclerosis. By reducing these B cells, Ocrevus slows disease progression and reduces relapses.

Manufacturer in the USA, Mexico, and Canada

  • 1
    United States: Genentech, Inc. (a member of the Roche Group).
  • 2
    Canada: Hoffmann-La Roche Limited (Roche Canada).
  • 3
    Mexico: Roche México S.A. de C.V.

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Approved in all three countries for relapsing MS and primary progressive MS.
  • Prescribing guidelines and monitoring requirements may vary depending on national standards.

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

  • 1
    Canada: Typically 20–30% savings compared to U.S. pricing.
  • 2
    Mexico: Typically 25–35% savings compared to U.S. pricing.

Savings are approximate, based on 2025 price data. They may vary depending on supply availability, prescription requirements, and infusion clinic costs.

Where to Buy USA

  • Costco
  • CVS
  • Rite Aid
  • Walgreens
  • Walmart
  • Kroger
  • Albertsons
  • Sam’s Club
  • Publix
  • Target (via CVS Pharmacy)
  • Online mail-order specialty care pharmacies

Availability may vary depending on insurance coverage, neurology specialty networks, and infusion center partnerships.

Storage Requirements

  • Store in a refrigerator (2°C–8°C / 36°F–46°F).
  • Do not freeze.
  • Keep vials in original carton to protect from light.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

________________________________________

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • First and only therapy approved for primary progressive multiple sclerosis (PPMS).
  • Reduces relapses and delays disability progression in relapsing MS.
  • Administered only twice per year after the initial loading dose.
  • Improves quality of life by decreasing MS activity and flare frequency.

Side Effects

Common side effects:

  • Infusion reactions (fever, rash, throat irritation, itching)
  • Upper respiratory tract infections
  • Skin infections

Serious but less common side effects:

  • Increased risk of infections (pneumonia, herpes virus reactivation)
  • Potential increased risk of malignancies, particularly breast cancer (ongoing monitoring)
  • Rare but serious infusion-related anaphylaxis

Warnings and Precautions

  • Must be administered by IV infusion in a medical facility.
  • Screen patients for hepatitis B before starting, as reactivation can occur.
  • Avoid live vaccines during treatment and for several months afterward.
  • Patients should be monitored for infusion reactions and infections.
  • Limited data in pregnancy; discuss risks with a healthcare provider.

Alternative Medications (by Indication)

  • Tysabri (natalizumab): For relapsing MS.
  • Kesimpta (ofatumumab): Subcutaneous B-cell depleting therapy for MS.
  • Rituxan (rituximab): Off-label for MS, B-cell targeting therapy.
  • Aubagio (teriflunomide): Oral MS treatment.
  • Tecfidera (dimethyl fumarate): Oral MS treatment.

Medication FAQs

Ocrevus is prescribed to treat adults with relapsing forms of multiple sclerosis and primary progressive multiple sclerosis.

It is given by intravenous (IV) infusion in a clinic or hospital every 6 months after the initial two-dose schedule.

Clinical trials show Ocrevus significantly reduces relapses and slows disease progression compared to standard therapies.

Infusions may take several hours. You may receive medications beforehand to reduce the risk of infusion reactions.

Live vaccines should be avoided. Inactivated vaccines may be given but should be discussed with your doctor.

No. It helps manage MS by reducing relapses and slowing progression, but it is not a cure.

Currently, Ocrevus is approved only for adults. Pediatric trials are ongoing.

Your doctor will check for hepatitis B, monitor infusion reactions, and watch for infections or malignancies.

Studies suggest it is effective and generally safe long-term, but monitoring is essential.

Yes. Patient assistance programs may be available in the U.S., Canada, and Mexico. MedicalMex helps patients explore affordable access options.