Oxervate (cenegermin-bkbj)

Product Name:

Oxervate (cenegermin-bkbj)

Categories: Ophthalmology, Rare Diseases

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Table of Contents

Oxervate (cenegermin-bkbj)

Product Category

Ophthalmology / Rare Diseases

Brand Name

Oxervate

Generic Name or Biosimilar

No

Active Ingredient

Cenegermin-bkbj (recombinant human nerve growth factor)

Prescription Status

Prescription-only in the United States, Mexico, and Canada.

Targeted Conditions

  • Neurotrophic keratitis: a rare, degenerative corneal disease that can cause vision loss.

Off-Label Usage

  • Currently no significant off-label uses. Oxervate is specifically approved for neurotrophic keratitis, a rare condition.

Drug Classification Overview

Oxervate is a recombinant form of human nerve growth factor (NGF). It promotes healing and regeneration of corneal nerves and tissues damaged in neurotrophic keratitis, helping to restore corneal integrity and preserve vision.

Manufacturer in the USA, Mexico, and Canada

  • 1
    United States: Dompé U.S. Inc.
  • 2
    Canada: Dompé Pharmaceuticals Canada, Inc.
  • 3
    Mexico: Dompé México S.A. de C.V.

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Approved in all three countries for treatment of neurotrophic keratitis.
  • Prescribing details, packaging, and storage guidelines may vary slightly by country.

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

  • 1
    Canada: Typically 20–25% savings compared to U.S. pricing.
  • 2
    Mexico: Typically 25–30% savings compared to U.S. pricing.

Savings are approximate, based on 2025 price data. They may vary depending on availability, prescription requirements, and cold-chain handling.

Where to Buy USA

  • Costco
  • CVS
  • Rite Aid
  • Walgreens
  • Walmart
  • Kroger
  • Albertsons
  • Sam’s Club
  • Publix
  • Target (via CVS Pharmacy)
  • Online mail-order specialty care pharmacies

Availability may vary depending on insurance coverage, ophthalmology specialty pharmacies, and prior authorization requirements.

Storage Requirements

  • Must be stored in a freezer at -20°C (-4°F) or lower before use.
  • After thawing, store in a refrigerator (2°C–8°C / 36°F–46°F).
  • Protect from light.
  • Each multi-dose vial must be used within the recommended timeframe after opening.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • First and only FDA- and EMA-approved therapy for neurotrophic keratitis.
  • Helps regenerate corneal nerves and repair corneal damage.
  • Reduces risk of corneal ulceration and potential blindness.
  • Provides a disease-modifying option rather than symptomatic relief.

Side Effects

Common side effects:

  • Eye pain
  • Ocular hyperemia (red eyes)
  • Increased tearing
  • Foreign body sensation in the eye

Serious but less common side effects:

  • Eye inflammation
  • Corneal deposits (rare)
  • Vision changes requiring medical evaluation

Warnings and Precautions

  • Must be prescribed and monitored by an ophthalmologist.
  • Patients may experience temporary discomfort at the site of application.
  • Not recommended for individuals with known hypersensitivity to cenegermin or any component of the product.
  • Limited data on safety during pregnancy and breastfeeding.

Alternative Medications (by Indication)

Currently, no direct alternatives to Oxervate exist, as it is the only therapy specifically targeting nerve regeneration in neurotrophic keratitis.

  • Lubricating eye drops / artificial tears: Symptomatic relief only.
  • Amniotic membrane transplantation or tarsorrhaphy: Surgical interventions used when medical therapy is not effective.
  • Autologous serum eye drops: Investigational therapy for neurotrophic keratitis.

Medication FAQs

Oxervate is prescribed to treat neurotrophic keratitis, a rare eye disease that can cause corneal damage and vision loss.

It is administered as eye drops, six times daily in the affected eye(s), over an 8-week treatment course.

It can promote healing and restore nerve function, but ongoing follow-up with an ophthalmologist is required.

Some patients notice improvements in eye health and comfort within weeks, but full corneal healing may take the full treatment course.

Yes, it has been approved for use in both adults and children with neurotrophic keratitis.

Apply the missed dose as soon as possible, but do not double up. Resume your regular schedule.

It must be kept frozen until use, then refrigerated once thawed, and used within the recommended timeframe.

Yes, but doses should be spaced at least 15 minutes apart. Your doctor will provide specific instructions.

Yes. Patient support programs may be available in the U.S., Canada, and Mexico. MedicalMex helps patients explore affordable access options.

Some patients may require more than one course of treatment, depending on their condition and corneal healing progress.