Trelegy Ellipta (Fluticasone furoate / Umeclidinium / Vilanterol)

Product Name:

Trelegy Ellipta

Categories: Allergy, Pulmonology

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Table of Contents

Trelegy Ellipta
(Fluticasone furoate / Umeclidinium / Vilanterol)

Product Category

Respiratory Therapy / Chronic Obstructive Pulmonary Disease (COPD) and Asthma Maintenance

Brand Name

Trelegy Ellipta

Generic Name or Biosimilar

No

Active Ingredient

Fluticasone furoate / Umeclidinium / Vilanterol

Prescription Status

Prescription-only

Targeted Conditions

Trelegy Ellipta is approved for the maintenance treatment of:

  • Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and/or emphysema
  • Asthma (in adults) that is not adequately controlled with inhaled corticosteroids and long-acting beta agonists

It is not indicated for the relief of acute bronchospasm.

Off-Label Usage

Though not formally approved, some specialists may prescribe Trelegy off-label for:

  • Refractory asthma in select pediatric populations (on a case-by-case basis)
  • Certain bronchiectasis conditions where triple therapy is deemed necessary

Drug Classification Overview

Trelegy Ellipta is a triple combination inhaler, consisting of:

  • Fluticasone furoate: an inhaled corticosteroid (ICS) that reduces inflammation
  • Umeclidinium: a long-acting muscarinic antagonist (LAMA) that helps relax airway muscles
  • Vilanterol: a long-acting beta2-adrenergic agonist (LABA) that opens the airways

This fixed-dose combination allows once-daily dosing for sustained symptom control.

Manufacturer in the USA, Mexico, and Canada

USA: GlaxoSmithKline (GSK)
Mexico: GlaxoSmithKline Mexico S.A. de C.V.
Canada: GlaxoSmithKline Inc. (Canada)

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Formulation: Equivalent active ingredients and therapeutic effect across all three countries
  • Packaging: Slight differences in labeling and box design per regulatory requirements
  • Language: Packaging and instructions are in English (Canada/USA) and Spanish (Mexico)
  • Manufacturer: Usually the same (GSK), but may vary by packaging site or affiliate brand

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

Canada: ~35–50% savings compared to U.S. retail prices
Mexico: ~40–55% savings compared to U.S. retail prices
These ranges may vary depending on medication availability, cold chain requirements, prescription needs, and inventory status.

Where to Buy USA

Costco, CVS, Rite Aid, Walgreens, Walmart, Kroger, Albertsons, Sam’s Club, Publix, Target (via CVS Pharmacy), and online mail-order specialty care pharmacies.

Availability may vary based on insurance, pharmacy network, and prescription requirements.

Storage Requirements

  • Store at room temperature, away from direct sunlight and moisture.
  • Do not puncture or burn the inhaler device, even when empty.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • Triple-action once-daily inhaler for COPD and asthma
  • Reduces flare-ups, improves lung function, and enhances quality of life
  • Convenient Ellipta device ensures ease of use and consistent dosing
  • FDA, Health Canada, and COFEPRIS approved (by country)
  • Avoids need for multiple inhalers
  • Suitable for long-term maintenance treatment

Side Effects

Common:

  • Headache
  • Upper respiratory tract infections
  • Sore throat
  • Cough
  • Hoarseness

Moderate to Serious:

  • Increased risk of pneumonia (especially in COPD)
  • Fungal infections (oral thrush)
  • Paradoxical bronchospasm
  • Cardiovascular side effects like tachycardia or palpitations
  • Hypokalemia

Always rinse your mouth after inhalation to minimize local side effects.

Warnings and Precautions

  • Not for acute asthma or COPD attacks
  • Increased risk of asthma-related death with LABA component (black box warning)
  • Monitor for glaucoma, urinary retention, and infections
  • Use with caution in patients with cardiovascular disease or arrhythmias
  • May interact with strong CYP3A4 inhibitors

Regular medical monitoring is advised.

Alternative Medications (by Indication)

For COPD: Anoro Ellipta, Stiolto Respimat, Symbicort

For Asthma: Symbicort, Advair, Breo Ellipta
Separate ICS + LAMA + LABA inhalers for stepwise therapy

Medication FAQs

It is a maintenance inhaler for adults with COPD or asthma, helping reduce symptoms, improve breathing, and prevent flare-ups.

Once daily — the triple-action formula is designed for 24-hour coverage.

Yes, it is approved for long-term maintenance therapy, under proper medical supervision.

No. Trelegy is not a rescue inhaler. You should have a fast-acting bronchodilator (like albuterol) for acute symptoms.

Yes. Pneumonia, fungal infections, bronchospasm, and heart-related issues are rare but possible. Report any unusual symptoms to your doctor.

Take it as soon as you remember unless it’s almost time for the next dose. Do not double dose.

It is typically covered by many insurance plans, but costs may vary based on your provider and tier placement.

We connect you with licensed pharmacies in Canada and Mexico that offer significantly lower pricing. We manage prescriptions, fulfillment, compliance, and offer personalized support throughout the process.

Yes. MedicalMex can arrange transportation, lodging, and prescription handling for pickup at a certified Tijuana location.

Yes, all orders require a valid prescription issued by a licensed physician.