Xtampza ER (oxycodone extended-release)

Product Name:

Xtampza ER (oxycodone extended-release)

Categories: Pain Management, Psychiatry

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Table of Contents

Xtampza ER
(oxycodone extended-release)

Product Category

Pain Management / Opioid Analgesics

Brand Name

Xtampza ER

Generic Name or Biosimilar

No

Active Ingredient

Oxycodone (extended-release)

Prescription Status

Prescription-only in the United States, Mexico, and Canada. Classified as a controlled substance (Schedule II in the U.S.).

Targeted Conditions

  • Management of severe pain requiring daily, around-the-clock, long-term opioid treatment where alternative options are inadequate.

Off-Label Usage

  • Rarely, opioids like oxycodone may be used in palliative care for refractory dyspnea (shortness of breath), though not specifically Xtampza ER.
  • Not widely used off-label due to strict regulatory controls.

Drug Classification Overview

Xtampza ER is an extended-release formulation of oxycodone, a semisynthetic opioid analgesic. It is designed for continuous pain relief and incorporates abuse-deterrent technology to reduce the risk of manipulation and misuse.

Manufacturer in the USA, Mexico, and Canada

  • United States: Collegium Pharmaceutical, Inc.
  • Canada: Distributed by licensed opioid manufacturers/importers under Health Canada approval.
  • Mexico: Distributed by certified pharmaceutical importers regulated by COFEPRIS.

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Approved in all three countries for the management of severe chronic pain.
  • Access and prescribing regulations differ significantly due to opioid control laws.
  • Canada and Mexico may have stricter dispensing requirements compared to the U.S.

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

Canada: Typically 20–30% savings compared to U.S. pricing.
Mexico: Typically 25–35% savings compared to U.S. pricing.

Savings are approximate, based on 2025 price data. They may vary depending on controlled substance regulations, availability, and prescribing requirements.

Where to Buy USA

  • Costco
  • CVS
  • Rite Aid
  • Walgreens
  • Walmart
  • Kroger
  • Albertsons
  • Sam’s Club
  • Publix
  • Target (via CVS Pharmacy)
  • Online mail-order specialty care pharmacies

Note: Restricted to licensed pharmacies with authority to dispense controlled substances.

Storage Requirements

  • Store at room temperature (20°C–25°C / 68°F–77°F).
  • Protect from moisture and light.
  • Keep in a secure location, away from children and individuals at risk of misuse.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • Provides extended pain relief for patients requiring continuous opioid therapy.
  • Abuse-deterrent formulation reduces risk of misuse compared to traditional oxycodone tablets.
  • Flexible dosing options for individualized treatment.
  • Can be taken with or without food, offering convenience.

Side Effects

Common side effects

  • Constipation
  • Nausea
  • Vomiting
  • Drowsiness
  • Dizziness
  • Headache

Serious but less common side effects

  • Respiratory depression (slowed or difficult breathing)
  • Dependence and addiction
  • Low blood pressure
  • Severe allergic reactions
  • Seizures (rare)

Warnings and Precautions

  • High potential for addiction, abuse, and misuse.
  • Risk of life-threatening respiratory depression.
  • Do not use with alcohol or sedative medications.
  • May cause neonatal opioid withdrawal if used during pregnancy.
  • Requires careful tapering to discontinue safely.
  • Contraindicated in patients with severe respiratory conditions or known hypersensitivity to oxycodone.

Alternative Medications (by Indication)

  • OxyContin (oxycodone ER): Another extended-release oxycodone product.
  • Morphine ER: Traditional opioid for long-term pain management.
  • Hydromorphone ER (Exalgo): Alternative long-acting opioid.
  • Fentanyl transdermal patch: Potent option for severe chronic pain.
  • Non-opioid alternatives: NSAIDs, duloxetine, pregabalin (depending on pain type).

Medication FAQs

Xtampza ER is prescribed for the management of severe, long-term pain that requires continuous opioid treatment.

It is an extended-release, abuse-deterrent formulation designed for continuous pain relief and reduced misuse potential.

Typically every 12 hours, but exact dosing is determined by the prescribing physician.

No. It is meant only for chronic, severe pain where other treatments are not effective.

Take it as soon as you remember unless it is almost time for your next dose. Do not double up.

Yes. Like all opioids, it carries a risk of dependence, addiction, and misuse.

No. Alcohol increases the risk of dangerous side effects, including respiratory depression.

Keep in a locked, secure location to prevent accidental or intentional misuse.

No. It is approved only for adults.

Yes. Assistance programs may be available in the U.S., Canada, and Mexico. MedicalMex helps patients explore affordable access options.