Xtandi (enzalutamide)

Product Name:

Xtandi (enzalutamide)

Categories: Hematology, Oncology

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Table of Contents

Xtandi (Enzalutamide)

Product Category

Oncology – Prostate Cancer Treatment

Brand Name

Xtandi

Generic Name or Biosimilar

No

Active Ingredient

Enzalutamide

Prescription Status

Prescription-only

Targeted Conditions

Xtandi is primarily approved for the treatment of:

  • Non-metastatic castration-resistant prostate cancer (nmCRPC)
  • Metastatic castration-resistant prostate cancer (mCRPC)
  • Metastatic castration-sensitive prostate cancer (mCSPC) in combination with androgen deprivation therapy (ADT)

It is used in adult male patients who are no longer responding to medical or surgical treatments that lower testosterone.

Off-Label Usage

Some clinicians may consider Xtandi for:

  • Triple-negative breast cancer (under clinical study)
  • Certain forms of recurrent or resistant ovarian or endometrial cancer (investigational)

Off-label uses must always be supervised by an oncologist.

Drug Classification Overview

Xtandi is classified as an androgen receptor inhibitor. It works by blocking the effects of androgens (male hormones) like testosterone, which can promote the growth of prostate cancer cells.

Manufacturer in the USA, Mexico, and Canada

  • 1
    USA: Astellas Pharma US, Inc.
  • 2
    Canada: Astellas Pharma Canada, Inc.
  • 3
    Mexico: Astellas Farma México, S.A. de C.V.

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

Xtandi in all three countries is manufactured by Astellas and maintains the same therapeutic effect. However, variations may exist in:

  • Packaging language (English vs Spanish vs bilingual)
  • Blister packs vs bottle formats
  • Pill imprint or design
  • Approved indications and labeling format

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

  • 1
    Canada: ~45–55% savings vs U.S. retail
  • 2
    Mexico: ~35–45% savings vs U.S. retail

Savings may vary depending on availability, prescription requirements, controlled status, and cold chain requirements (if applicable).

Where to Buy USA

Xtandi is available at the following U.S. pharmacies:

  • CVS
  • Walgreens
  • Rite Aid
  • Walmart
  • Costco
  • Kroger
  • Albertsons
  • Sam’s Club
  • Publix
  • Target (via CVS Pharmacy)
  • Online mail-order specialty care pharmacies

Availability may vary depending on insurance coverage, specialty pharmacy requirements, and oncology treatment plans.

Storage Requirements

Xtandi should be stored at room temperature, away from moisture and heat. Do not refrigerate or expose to excessive humidity.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • Oral administration, eliminating need for injections
  • Extends survival in men with advanced prostate cancer
  • Delays cancer progression in early stages of resistance
  • Can be taken with or without food
  • Often used when hormone therapy alone is no longer effective

Side Effects

Common side effects may include:

  • Fatigue
  • Hot flashes
  • Joint pain
  • Diarrhea
  • High blood pressure
  • Headache

Serious side effects may include:

  • Seizures (rare)
  • Falls or fractures
  • Cognitive changes (e.g., memory or concentration difficulties)
  • Risk of hypertension and cardiac complications

Warnings and Precautions

  • Not for use in women, children, or adolescents
  • May increase risk of seizures — avoid if history of seizure disorder
  • Use with caution in patients with liver or kidney impairment
  • Monitor blood pressure and cardiovascular health regularly
  • Inform your doctor of all medications to avoid interactions

Alternative Medications (by Indication)

  • Zytiga (abiraterone acetate)
  • Erleada (apalutamide)
  • Nubeqa (darolutamide)
  • Lupron Depot (leuprolide acetate – injectable)
  • Orgovyx (relugolix – oral hormone therapy)

Medication FAQs (Patient-Oriented Answers)

Xtandi is used to treat advanced forms of prostate cancer that are either resistant to hormone therapy or that have spread (metastasized).

No. Xtandi is not a traditional chemotherapy. It is a targeted therapy that blocks androgen receptors to stop prostate cancer cells from growing.

It is taken orally once a day, usually at the same time each day. It can be taken with or without food.

Duration varies by individual, but many patients take Xtandi for months or years depending on disease progression and tolerability.

Seizures are a rare but serious side effect. Patients with a history of seizures or head trauma should consult their doctor before starting Xtandi.

No. Xtandi is not approved for use in women and can cause harm if taken during pregnancy.

Yes. Patients may need regular blood pressure checks, blood tests, and evaluations for cognitive changes or fatigue.

Buying from Canada may offer 45–55% savings, and from Mexico around 35–45% compared to U.S. retail prices. Savings vary depending on availability and prescription needs.

In the U.S., many insurance plans cover Xtandi under oncology specialty drug benefits, though prior authorization is often required.

No. Xtandi requires a valid prescription from a licensed physician in all countries.