Zytiga (abiraterone acetate)

Targeted Conditions

Zytiga is primarily indicated for the treatment of:

  • Metastatic castration-resistant prostate cancer (mCRPC)
  • Metastatic high-risk castration-sensitive prostate cancer (mCSPC)

Both are treated in combination with prednisone.

Off-Label Usage

Some off-label or investigational uses include:

  • Advanced breast cancer (under clinical study)
  • Ovarian cancer (experimental settings)

Any off-label use should be overseen by a qualified oncologist.

Drug Classification Overview

Zytiga belongs to a class of medications called androgen biosynthesis inhibitors. It blocks an enzyme (CYP17A1) necessary for the production of testosterone, which fuels prostate cancer growth.

9. Manufacturer in the USA, Mexico, and Canada

  • 1
    USA: Janssen Biotech, Inc.
  • 2
    Canada: Janssen Inc.
  • 3
    Mexico: Janssen-Cilag, S.A. de C.V.

Available Strengths and Dosage Forms – United States, Mexico, and Canada

Country Comparison – United States vs Mexico and Canada

  • Zytiga is manufactured by Janssen in all three markets, offering consistent therapeutic effects.
  • Differences may exist in labeling (English, Spanish, or bilingual), pill imprint, or packaging materials.
  • Generic versions are more widely available in Canada and Mexico, offering significant cost reductions while maintaining efficacy.

Average Retail Price (Monthly Treatment) USA vs Mexico vs Canada

  • 1
    Canada: ~50–60% savings vs U.S. retail
  • 2
    Mexico: ~40–50% savings vs U.S. retail

These savings are approximate and may vary based on generic availability, cold chain handling, prescription verification, and supply.

Where to Buy USA

Zytiga is available at:

  • CVS
  • Walgreens
  • Rite Aid
  • Walmart
  • Costco
  • Kroger
  • Albertsons
  • Sam’s Club
  • Publix
  • Target (via CVS Pharmacy)
  • Online mail-order specialty care pharmacies

Availability and pricing may vary depending on insurance coverage and pharmacy networks.

Storage Requirements

Store at room temperature (68°F–77°F or 20°C–25°C), in a dry place. Protect from excessive moisture or heat.

Shipping from Canada

This medication is accessed through fully licensed Canadian pharmacies regulated by Health Canada. All pharmacies included in the MedicalMex network undergo a rigorous review and verification process to ensure compliance with national standards, patient safety, and medication authenticity.

MedicalMex facilitates:

  • Prescription verification and fulfillment coordination
  • Secure, compliant medication logistics
  • Access to licensed Canadian pharmacists
  • Access to our network of certified physicians if a Telehealth consultation is needed
  • Case management, payment handling, and personalized boutique-level support
  • Cold chain shipping with next-generation temperature-monitored coolers, when required
  • Refill tracking and patient adherence programs

You are working directly with MedicalMex Inc., a U.S.-based company that helps eligible patients safely access affordable medications from Canada — with compliance and full-service concierge support at every step.

Buying from Mexico

This medication is also available through certified pharmacies in Mexico regulated by COFEPRIS (Mexico’s national health authority). All partners in the MedicalMex network must pass a rigorous review and certification process before being approved for patient access.

MedicalMex facilitates:

  • Transportation support to our affiliate clinic in Tijuana, Mexico
  • Prescription handling through licensed physicians within our certified network
  • Access to our network of accredited physicians if a Telehealth consultation is needed
  • Travel coordination, including flights and/or hotel reservations when required
  • Travel insurance
  • Cold chain shipping with advanced temperature-monitored coolers, when applicable
  • Personalized, boutique-level service
  • Refill tracking and patient adherence support

You are working directly with MedicalMex Inc., a U.S.-based company that manages every detail — from medical and travel logistics to prescription compliance — providing secure, affordable access to life-saving medications from Mexico.

Key Benefits

  • Proven to extend overall survival in men with metastatic prostate cancer
  • Works by lowering testosterone at the cellular level
  • Oral administration — taken at home
  • Available in generic versions for cost savings
  • Often part of a combined therapy plan with prednisone

Side Effects

Common side effects include:

  • Joint pain
  • Fatigue
  • Hot flashes
  • Fluid retention
  • Hypertension

More serious or rare effects:

  • Liver function abnormalities
  • Adrenal insufficiency
  • Hypokalemia (low potassium)
  • Increased risk of infections
  • Elevated blood pressure

Warnings and Precautions

  • Not for use in women or children
  • Can harm an unborn baby — contraindicated in pregnancy
  • Liver function should be monitored before and during treatment
  • Use caution in patients with cardiovascular disease
  • Must be taken with prednisone to reduce risk of side effects
  • Avoid food for at least 2 hours before and 1 hour after taking Zytiga

Alternative Medications (by Indication)

  • Xtandi (enzalutamide)
  • Erleada (apalutamide)
  • Nubeqa (darolutamide)
  • Lupron Depot (leuprolide acetate – injectable)
  • Orgovyx (relugolix – oral hormone therapy)

Medication FAQs (Patient-Oriented Answers)

Zytiga is used to treat metastatic castration-resistant prostate cancer (mCRPC) and high-risk metastatic castration-sensitive prostate cancer (mCSPC), typically alongside prednisone.
It blocks an enzyme (CYP17) that helps the body produce androgens (male hormones like testosterone), which prostate cancer cells need to grow.
No. Zytiga is a hormone-based therapy, not traditional chemotherapy.
Prednisone helps reduce side effects from the hormonal changes caused by Zytiga and supports adrenal gland function.
No. It must be taken on an empty stomach — no food 2 hours before or 1 hour after taking the dose.
It varies by individual response, but many patients stay on Zytiga for several months to years with regular monitoring.
Worsening PSA levels, symptoms, or radiologic progression may indicate resistance or need for alternative therapies.
Yes, it may affect liver enzymes. Blood tests are typically done regularly to monitor liver function.
You may save approximately 50–60% in Canada and 40–50% in Mexico compared to U.S. retail pricing. Savings depend on whether you use the brand or generic version and other variables.
No. A valid prescription is required in all countries. MedicalMex coordinates the entire fulfillment process with licensed providers.